![]() ![]() It remains unclear to what extent HPV transmission events occur from hand-to-genital or genital-to-hand contact. 11 The high correlation between hand and genital HPV detections makes it difficult in most studies to separate cause from effect and the directionality of transmission. 8 However, there has always been skepticism as to the importance of hand-to-genital transmission of alpha HPV types. ![]() 4– 8 This hypothesis is supported by the frequent detection of alpha HPV DNA on hands and under fingernails, 8– 10 as well as the high concordance between hand and genital HPV types in the same person 6, 9 and between partners. 3 Over the years, some have also speculated as to the possibility of hand-to-genital transmission of alpha HPV types. ![]() 2 Because HPV prevalence is highly correlated with the number of recent and lifetime genital sex partners, a large body of evidence suggests alpha HPV types are mainly transmitted through genital-to-genital contact. 1 Alpha HPV types mainly infect mucosal tissues. Human papillomavirus (HPV) types of the genus Alphapapillomavirus (alpha) are sexually transmitted infections, many of which cause anogenital and oropharyngeal cancers in men and women. ![]()
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